Mefuta e phahameng ea Homocysteine le mathata a Bokhachane
Haeba u kile ua e-ba le ho senyeha ha maikutlo ka makhetlo a mangata, ngaka ea hau e ka 'na ea buella ho hlahloba boemo ba homocysteine maling a hao. Hantle-ntle homocysteine ke eng? Ho joang homocysteine e amana le ho senyeheloa ke mpa le mathata a mang a bokhachane?
Homocysteine ke Eng?
Homocysteine ke mofuta oa amino acid eo ka tlhaho e fumanehang 'meleng. Maemong a tloaelehileng, ha se kotsi, empa maemo a phahame a fumanoe a amana le ho senyeheloa ke mpa hammoho le lefu la pelo.
Lebelo le phahameng la Homocysteine
Lebelo le phahameng la homocysteine maling a fella ka boemo bo tsejoang e le hypercoagulability. Lentsoe coagulation le bolela ho koala mali, 'me hypercoagulability e bolela hore mali a koala habonolo ho feta kamoo a lokelang.
Ha sena se etsahala meleng ea mali, e kang methapo ea mali, e ka kenya letsoho ho thibela methapo ea mali e bakang lefu la methapo ea mali.
Ho na le moimana, ho nahanoa hore li-clots tse nyane tsa mali li ka 'na tsa thibela methapo ea mali ka placenta, e lebisang ho senyeheloa ke mpa.
Phaello e phahameng ea Homocysteine le ho tsoa malapeng
Elevated homocysteine ha e e-s'o hlahe ho baka ho senyeheloa ke mpa, empa ho na le lintho tse ling tse tloaelehileng tse nang le maemo a mang a tsebahalang a lebisang ho senyeheloa ke mpa. Boemo bo bong, bo bitsoang antiphospholipid syndrome , bo ka fella ka ho senyeheloa ke mpa le lefu la pelo ka tsela e ts'oanang.
Mathata a mang a bokhachane
Elevated homocysteine e netefalitsoe ke kotsi ea mathata a mang nakong ea bokhachane ho akarelletsa:
- Nete e fokotsehileng
- Mathata a tsoaloang a Congenital, a kang a neural tube litšitiso tse kang anencephaly
- Preeclampsia
- Lebelo la ho hōla ha li-intrauterine
Joaloka tabeng ea ho senyeheloa ke mpa, bopaki bo khahlanong le hore na litekanyetso tse phahameng tsa homocysteine li baka mathata a mang a bokhachane, a kang:
- Ho senyeha ka mokhoa o tšabehang
- Down syndrome
Phehisana ha ho hlahloba Plasma ea ho itima lijo Homocysteine (THcy) nakong ea Bokhachane
Haeba ngaka ea hau e hlahloba boemo ba homocysteine, ke habohlokoa ho tseba hore maemo a tloaelehileng a homocysteine nakong ea bokhachane. Ka mantsoe a mang, tekanyo e nkiloeng ka nako e le 'ngoe e ka' na ea se ke ea emela hore na maemo a hau ke afe ka nako e kholo. Ho na le mabaka a 'maloa a phepo e nepahetseng le a bophelo a etsang hore letsatsi le leng le le leng ho be le mefuta e sa tšoaneng. Ho phaella moo, liphetoho tsa mali a amanang le bokhachane li kopantsoe le liphetoho tse ngata tsa li-hormone li ka fella ka litekanyetso nakong ea bokhachane e sa bolele hore na maemo a hau ke afe ha u sa ima.
Metabolism le Genetics ea Maemo a Homocysteine
Haeba u na le maemo a phahameng a homocysteine, liphatsa tsa hau tsa lefutso e ka ba sesosa.
Batho ba nang le phapang mophatleng oa MTHFR , haholo-holo mefuta ea C677T, ba na le menyetla e phahameng ea ho ba le homocysteine. 'Me lipatlisiso tse ling li fumane hore ho na le kamano pakeng tsa liphatsa tsa lefutso tsa MTHFR le ho eketseha ha kotsing ea ho senyeheloa ke mpa. Taba e ka sehloohong ea mokhatlo ona ke hore litekanyetso tse phahameng tsa homocysteine ho batho ba nang le liphatsa tsa lefutso tsa MTHFR li baka kotsi ea ho senyeheloa ke mpa.
Lingaka tse ling li lekoa bakeng sa liphatsa tsa lefutso tsa MTHFR e le karolo ea tlhahlobo ea meriana e tloaelehileng ea ho senyeheloa ke mpa .
Ba bang ba nka hore ke habohlokoa haholo ho leka homocysteine hobane ha ho motho e mong le e mong ea nang le liphatsa tsa lefutso tsa MTHFR tse nang le li-amino acid tse phahameng.
Lisosa
MTHFR liphatsa tsa lefutso hase tsona feela tse bakang homocysteine e phahameng.
MTHFR liphatsa tsa lefutso hase tsona feela tse bakang homocysteine e phahameng. 'Mele oa hau o sebelisa limatlafatsi tsa folic acid , vithamine B6 le vithamine B12 ho metabolize kapa ho sebelisa, homocysteine. Batho ba haelloang ke li-vithamine tseo ba ka ba le maemo a phahameng a homocysteine.
Mefuta e sa tšoaneng ea bophelo bo botle le meriana e ka boela ea amana le maemo a phahameng a homocysteine.
Tse ling tsa Likotsi tsa Bophelo
Le hoja karolo e tobileng e sa tsejoe, maemong a phahameng a homocysteine a 'nile a fumanoa ka ho tšoaroa ha masapo a pelo, ho hlaseloa ke pelo, ho otloa ke lefu, ho tepella maikutlo, lefu la Parkinson, multiple sclerosis le lefu la sethoathoa.
Ho nahanoa hore maemong a phahameng a homocysteine maling a ka 'na a ba le liphello tse kotsi tse kotsi ho tsamaiso ea methapo ea methapo le ea methapo.
Ho Phekola Homocysteine e Phahameng ka Litsela Tse sa Lebelloang
Ha ho na litlhahiso tse hlophisitsoeng ho hlahloba litekanyetso tsa homocysteine ho basali ba nang le ho senyeheloa ha meriana, hape ha ho na melaetsa ea kalafo e khothalletsoang ke bokahohleng bakeng sa ho sebetsana le maemo a phahameng a homocysteine ho basali ba fumanoang ba e-na le bona.
Leha ho le joalo, lingaka tse ling li leka homocysteine (kapa liphatsa tsa lefutso tsa MTHFR) ho basali ba nang le ho lahleheloa ke bokhachane khafetsa le ho khothalletsa phekolo esita leha ho se na likomelo tse tloaelehileng.
Keletso e tloaelehileng ho basali ba nang le maemo a phahameng a homocysteine ke ho nka tekanyo e phahameng ea folic acid le li-vithamine tsa B ho ntlafatsa metabolism ea 'mele ea homocysteine. Etsa joalo feela ka litlhahiso tsa ngaka ea hau, leha ho le joalo, kaha litekanyetso tse phahameng tsa livithamine tsena li ka 'na tsa se ke tsa baka litla-morao feela empa li ka kena-kenana le ho kenngoa ha livithamine tse ling. Bakeng sa ba nang le liphatsa tsa lefutso tsa MTHFR, li-supplemental folic acid ha li fumanoe li fokotsa kotsi ea ho senyeheloa ke mpa.
Lingaka tse 'maloa li ka' na tsa khothaletsa phekolo ea ho thibela, e kang heparin kapa aspirin ea tekanyo e tlaase , e le hore thibelo ea mali e se ke ea etsoa nakong ea bokhachane, empa mokhoa ona ha o tloaelehe.
Ka lehlohonolo, ho na le lithuto tse ntseng li tsoela pele ho sheba likarabo lipotsong tse peli mabapi le hore na karolo e phahameng ea homocysteine e na le eng nakong ea bokhachane le tsela e molemohali ea ho li tšoara haeba e le teng.
Lisebelisoa:
Ansari, R., Mahta, A., Mallack, E., le J. Luo. Hyperhomocysteinemia le Mathata a Neurological: Tlhahlobo. Journal of Clinical Neurology . 2014. 10 (4): 281-8.
Hekmatdoost, A., Vahid, F., Yari, Z., Sadeghi, M., Eini-Zinab, J., Lakpour, N., le S. Arefi. Methyltetrahydrofolate vs Folic Acid Supplementation ka ho tlosoa ha Meriana e tloaelehileng ea Idiopathie ka tlhompho ea Methylenetetrahydrofolate Reductase C677T le A1298C Polymorphisms: Tlhahlobo e laoloang ka nako e tloaelehileng. PLoS One . 2015. 10 (12): e0143569.
Levin, B., le E. Varga. MTHFR: Ho buisana le mekhoa ea ho fana ka tlhabollo ea liphatsa tsa lefutso ho sebelisa libuka tse fanoeng ka bopaki. Journal of Counseling Counseling . 2016. 25 (5): 901-11.
Puri, M., Kaur, L., Walia, G., Mukhopadhhyay, R., Sachdeva, M., Triveldi, S., Ghosh, P., le K. Saraswathy. MTHFR C677T Polymorphism, Folate, Vithamine B12 le Homocysteine ka ho Lahleheloa ke Bokhachane bo sa Lebelloang: Thuto ea ho Laola Tlhaho har'a Basali ba Amerika Leboea. Leqephe la Meriana ea Perinatal . 2013. 41 (5): 549-54.
Murphy, M., le J. Fernandez-Ballart. Homocysteine nakong ea Bokhachane. E tsoetseng pele setsing sa meriana . 2011. 53: 105-37.