Ke hobane'ng ha heparin le aspirin li ka thusa
Ha mali a hao a koala, liprotheine tse ngata 'meleng oa hau, har'a tsona Factor V, li sebetsa hammoho ho etsa hore ho etsahala; Ntlha ea V Leiden ke ho fetoha ha liphatsa tsa lefutso tsa Factory V e amang tsela ea ho thibela mali le ho etsa hore motho a be le monyetla o moholo oa ho theha mali.
Ithute ho eketsehileng ka ho fetoha ha liphatsa tsa lefutso le hore na e ka ba le phello efe nakong ea bokhachane le tlhahlobo ena.
Likopi tsa Factor V Leiden Gene
Motho a ka ba le kopi e le 'ngoe ea liphatsa tsa lefutso tsa Factor V Leiden le kopi e le' ngoe e tloaelehileng (e bolelang hore motho ke heterozygous), kapa motho a ka ba le likopi tse peli tsa Factory V Leiden gene (motho eo ke motho ea nang le bokooa).
Lingaka tse ling li khothalletsa basali ba heparin hore ba fokotsehe ka makhetlo a mangata ba hlahelang bothata ba Factor V Leiden. Botsa ngaka ea hau haeba a buella heparin, meriana e meng kapa meriana leha e le efe ho uena.
Phephetso ea Protein C
Sefate sa Factor V Leiden se boetse se amahanngoa le boemo bo bitsoang bo-ralitene ba protheine C. Protheine C ke protheine e 'ngoe e amehang nakong ea ho koala. Boholo ba batho ba nang le protheine ea C ea ts'oaetso e ntseng e sebelisoa ba boetse ba na le phapang ea liphatsa tsa lefutso tsa Factor V Leiden. Kahoo, basali ba bangata ba sa hlahlojoang ka ho khetheha bakeng sa liphatsa tsa lefutso tsa Factor V Leiden ba ka fumana hore ke bajari ka mor'a hore ba leke tlhahlobo ea protheine C.
Lipalo-palo
Hoo e ka bang liphesente tse 4 ho isa ho 7 lekholong ea baahi ke heterozygous bakeng sa Factor V Leiden.
Hoo e ka bang karolo ea 0,06 lekholong ho ea ho karolo ea 0.25 lekholong ea baahi ke homozygous bakeng sa Factor V Leiden. Mefuta e sa tšoaneng e na le litekanyo tse fapaneng tsa phetoho ea Factory V Leiden; e atile haholo ho batho ba tsoang Europe leboea. Bua le ngaka ea hau ka hore na u kotsing kapa che.
Likotsi
Ntlha ea V Leiden e bolela kotsi e eketsehileng ea bothata bo tebileng ba meriana ea mali le meriana ea bohlokoa ea mali.
Liphuputso tse ling li hlokometse hore ho ba le phetoho ea Factory V Leiden ho bolela kotsi e eketsehileng ea ho senyeha ha meriana ka makhetlo a mangata, mohlomong ka lebaka la li-clots tse nyenyane tsa mali tse thibelang ho phalla ha limatlafatsi ho placenta.
Phekolo
Nakong ea bokhachane, lingaka tse ling li lumela ho sebelisa heparin le / kapa aspirin ea tekanyo e tlaase ho tšoara basali ba nang le liphatsa tsa lefutso tsa Factor V Leiden le histori ea ho senyeha ha maikutlo. Hona joale, bafuputsi ba ntse ba ithuta kalafo ena ho tiisa hore e hlile e thusa. Litsi tsa mekhatlo e mengata ea ho ikatisa li khothalletsa bakuli hore ba nke aspirin lesea nakong ea phekolo feela haeba ba e-na le mathata a ho thibela.
Likamano le Meriana
Bafuputsi ba sa ntsane ba ithuta hantle hore na kamano e teng pakeng tsa Factor V Leiden (le tse ling tse nang le mahlaba a lefutso) le ho senyeha ha maikutlo hangata. Matšoao a fapaneng a liphatsa tsa lefutso tsa ho thibela mali a na le likarolo tse sa tšoaneng tsa kamano ea ho senyeheloa ke mpa, empa Factor V Leiden ke e 'ngoe ea li-thrombophilias tse futsanehileng tse bonahalang li e-na le karolo e bakang ho senyeha ha maikutlo (kapa bonyane ho beha kotsi) hobane basali ba nang le phetoho e kholo ho senyeha ha mpa ho feta basali ba se nang eona.
Phuputso e fumanehang e fana ka maikutlo a hore Factor V Leiden e ka phetha karolo ea ho senyeha ha maikutlo kamora libeke tse 10 empa ha ho bonolo hore e be sesosa sa ho senyeha ha maikutlo pele ho nako.
Lingaka tse ngata li leka tlhahlobo ea Factor V Leiden e le karolo ea tlhahlobo ea liteko tsa meriana e tloaelehileng ea ho senyeheloa ke maikutlo le ho khothalletsa phekolo ho ba nang le maikutlo a nepahetseng.
Lisebelisoa:
Coulam, CB, RS Jeyendran, LA Fishel le R. Roussev, "Mefuta e mengata ea phetoho ea liphatsa tsa lefutso ho e-na le liphetoho tse itseng tsa liphatsa tsa lefutso ke lisosa tse kotsi tsa ho senyeheloa ha mpa khafetsa." Journal ea Amerika ea Immunology ea Lefuba la Tsoalo May 2006.
Foka, ZJ, AF Lambropoulos, H. Saravelos, GB Karas, A. Karavida, T. Agorastos, V. Zournatzi, PE Makris, J. Bontis, le A. Kotsis, "Factory V leiden le prothrombin G20210A liphetoho, empa ha se methylenetetrahydrofolate ho fokotsa C677T, li amahanngoa le ho senyeha ha maikutlo ka linako tse ling. " Feb 2000.
Jivraj, S., R. Rai, J. Underwood, le L. Regan, "Ho fetoha ha liphatsa tsa lefutso ho batho ba nyalaneng ba nang le khaello ea ho senyeha." Ho Hlahisoa ha Batho ka May 2006.
Reznikoff-Etievan, MF, V. Cayol, B. Carbonne, A. Robert, F. Coulet, le J. Milliez, "Factor V Leiden le G20210A liphetoho tse feto-fetohang ke maemo a kotsi ka lebaka la ho senyeheloa ha mantlha hangata. ' BJOG Dec 2001.
University of Illinois - Urbana / Champaign, "Matšoao a Mamello: Factor V Leiden." Leqephe la Lisebelisoa la Hematology .
Walker, MC, SE Ferguson, le VM Allen, "Heparin bakeng sa bakhachane ba nang le li-thrombophilia tse fumanoeng kapa tse futsitsoeng." Laebrari ea Cochrane 21 Jan 2003.